Yes, but in the Restricted Zone (within 50 km of the coast or 100 km of borders, which covers Tulum and Playa del Carmen) only through a fideicomiso bank trust or a Mexican company; direct ownership elsewhere.
Quintana Roo: mandatory RETUR-Q registration (since Aug 2025, renewed annually) plus a state operating licence and RFC tax ID; 6% lodging tax; fines up to MXN 100,000.